Alcoholic Liver Disease – The Possibility of Ayurvedic Therapy
Kulkarni, R.D.Consulting Physician, Clinical Pharmacology, Bombay, India.‘
Scientists’ often frown on the multiple ingredients in Ayurvedic formulation. This is a manifestation of ignorance of Ayurveda and a lack of perception of modern drug development. Ayurvedic pharmacy is a highly sophisticated discipline and formulations are aimed at enhancing the bioavailability of desired constituents, reducing the bioavailability of undesirable constituents, thus providing targeted delivery of the active principle to avoid unwanted widespread effects. Modern western medicine is still groping to achieve these objectives. In fact, modern medicine has learnt the hard way, that the so called “inert” substances in the single drug oral preparations are after all not so inert (Melikian et. al., 1977). Modern medicine has developed a scientific methodology to test concepts and hypotheses but lacks “a priori” conceptual base. Ayurveda has a powerful conceptual content but lacks easily available methodology to test it. Only the serious study and blend of both will lead innovative research and the rapid progress of safe therapeutics.
REFERENCES
1, Chauhan B.L., Kulkarni, R.D., Effect of Liv.52, a herbal preparation on absorption and metabolism of ethanol in humans, European. Clin. Pharmacol. (In press).
2. Chauhan B.L., Modified head space gas chromatography method for quantitation of ethanol and acetaldehyde in blood. (To be published).
3. Holtzman, J.L., Gebhard, R.L., Eckfeldt, J.H., Mottonen, R.L., Finley, D.K. The effect of several weeks of ethanol consumption in ethanol kinetics in men and women. Clin Pharmocol. and Therap. 1985; 38: 157.
4. Korsten, M.A., Matsuzaki, S., Feinman L., Lieber, C.S. High blood acetaldehyde levels after ethanol administration. New Eng J. Med. 1978; 299:386.
5. Kulkarni, R.D., Recent Strategy for research in traditional medicine in India. Proc. Internat. Symp on Traditional Medicine and Modern Pharmacology, Beijing, 1986.
6. Lieber, C.S., Biochemical and molecular basis of alcohol induced injury to liver and other tissues. New Eng J. Med. 1988; 319: 1639.
7. Melikian, A.P., Straughn, A.B., Slywka, G.W.A., Whyatt, P.L., Meyer, M.C., Bioavailability of 11 Phenytoin products. J. Pharmacokinet. Biopharm. 1977; 5: 133.
8. Sorrell, M.F., Tuma, D.J., Hypothesis: Alcoholic liver injury and the covalent binding of acetaldehyde. Alcoholism, Clinical and Experimental Research 1985; 9: 306.
Refference: http://www.himalayahealthcare.com/pdf_files/liv193.pdf
Scientists’ often frown on the multiple ingredients in Ayurvedic formulation. This is a manifestation of ignorance of Ayurveda and a lack of perception of modern drug development. Ayurvedic pharmacy is a highly sophisticated discipline and formulations are aimed at enhancing the bioavailability of desired constituents, reducing the bioavailability of undesirable constituents, thus providing targeted delivery of the active principle to avoid unwanted widespread effects. Modern western medicine is still groping to achieve these objectives. In fact, modern medicine has learnt the hard way, that the so called “inert” substances in the single drug oral preparations are after all not so inert (Melikian et. al., 1977). Modern medicine has developed a scientific methodology to test concepts and hypotheses but lacks “a priori” conceptual base. Ayurveda has a powerful conceptual content but lacks easily available methodology to test it. Only the serious study and blend of both will lead innovative research and the rapid progress of safe therapeutics.
REFERENCES
1, Chauhan B.L., Kulkarni, R.D., Effect of Liv.52, a herbal preparation on absorption and metabolism of ethanol in humans, European. Clin. Pharmacol. (In press).
2. Chauhan B.L., Modified head space gas chromatography method for quantitation of ethanol and acetaldehyde in blood. (To be published).
3. Holtzman, J.L., Gebhard, R.L., Eckfeldt, J.H., Mottonen, R.L., Finley, D.K. The effect of several weeks of ethanol consumption in ethanol kinetics in men and women. Clin Pharmocol. and Therap. 1985; 38: 157.
4. Korsten, M.A., Matsuzaki, S., Feinman L., Lieber, C.S. High blood acetaldehyde levels after ethanol administration. New Eng J. Med. 1978; 299:386.
5. Kulkarni, R.D., Recent Strategy for research in traditional medicine in India. Proc. Internat. Symp on Traditional Medicine and Modern Pharmacology, Beijing, 1986.
6. Lieber, C.S., Biochemical and molecular basis of alcohol induced injury to liver and other tissues. New Eng J. Med. 1988; 319: 1639.
7. Melikian, A.P., Straughn, A.B., Slywka, G.W.A., Whyatt, P.L., Meyer, M.C., Bioavailability of 11 Phenytoin products. J. Pharmacokinet. Biopharm. 1977; 5: 133.
8. Sorrell, M.F., Tuma, D.J., Hypothesis: Alcoholic liver injury and the covalent binding of acetaldehyde. Alcoholism, Clinical and Experimental Research 1985; 9: 306.
Refference: http://www.himalayahealthcare.com/pdf_files/liv193.pdf
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