Studies on Liv.52 in hepatic disorders

Part II: Indian Childhood Cirrhosis and Miscellaneous Conditions — 97 Cases
Sharma, N.L., M.D., D.C.H. (Lond.), F.R.S.T.M.&H. (Eng.), D.T.M., D.P.H. (Cal.), Professor and Head of the Department of Pediatrics
Lahori, U.C., M.D., D.C.H., Research Scholar and
Mehta, S.K., B.Sc., M.B.,B.S., D.C.H., Research Scholar, King George’s Medical College, Lucknow, U.P., India.

Table XII: L.F.T. in non-specific cases with Liv.52 treatment (31 cases*)
Time		Serum protein in gm%										Serum bilirubin in mg%												Thymol turbidity
Up to 4			4 – 5		5 – 6		6 – 7		over 7		Upto 2		2 – 5		5 – 10		3 – 13		14–30		31–50		1 – 4		4 – 8
Initially		11		15		4		–		–		30		–		–		14		12		4		25		5
After 2 weeks		3		16		7		1		–		27		–		–		23		4		–		25		2
After 4 weeks		–		3		14		3		2		22		–		–		20		2		–		22		–
* In one case no L.F.T. was done

Table XIII: L.F.T. in non-specific group without Liv.52 treatment (25 cases*)
Time		Serum protein in gm%										Serum bilirubin in mg%												Thymol turbidity
Up to 4			4 – 5		5 – 6		6 – 7		over 7		Upto 2		2 – 5		5 – 10		3 – 13		14–30		31–50		1 – 4		4 – 8
Initially		10		11		2		–		–		23		–		–		10		11		2		21		2
After 2 weeks		6		15		2		–		–		23		–		–		12		10		1		22		1
After 4 weeks		1		12		3		2		1		18		–		–		12		6		–		18		–
* L.F.T. could not be done in 2 cases.

In this study an attempt is made to study the effects of Liv.52 in three groups of cases (a) viral hepatitis (b) Infantile cirrhosis of liver, Stages I and II, I.C.M.R. and (c) miscellaneous group. This study also shows the behaviour and functional response of liver cells in a number of conditions affecting young children. It is a well-known observation that young liver cells have a particularly high susceptibility to noxious substances and are thereby liable to be damaged readily. It is also true that the liver is one organ in the body that has a remarkable capacity for regeneration. What are the precise factors which tend to strike a balance between the functional efficiency and its deterioration, is difficult to say since liver function tests and even at times liver biopsy slides may fail to give a clear picture of the state of

Photomicrographs showing fatty infiltration of kwashiorkor.

liver cells. Under these handicaps the task of precise evaluation of the effectiveness of a particular drug becomes all the more difficult. Nevertheless, using as scientific an approach as possible, certain tentative conclusions have emerged from the foregoing study which are briefly summarised as below:
SUMMARY

1. In early stages of Indian Childhood Cirrhosis a certain degree of improvement in symptoms and some improvement in liver function tests was observed compared to the control group without Liv.52. This was during the period of study. The ultimate outcome of these cases cannot be predicted.

2. In the miscellaneous group with hepatomegaly there was improvement in symptoms, decrease in liver size and improvement in liver function tests.

I Three groups of cases: 58 of viral hepatitis, 41 of early stages I & II infantile cirrhosis of the liver, 56 miscellaneous group,

were studied for the effect of Liv.52. In each group control cases were studied simultaneously.

(i) Liv.52 was very effective in infective hepatitis,

(ii) Liv.52 helped in early cases of infantile cirrhosis of liver,

(iii) In the miscellaneous group Liv.52 led to regression of liver size, symptomatic relief and weight gain,

(iv) There were no toxic effects.

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