Some Observations on Liv.52 in the Treatment of Infective Hepatitis and Cirrhosis of Liver
Lala Surajnandan Prasad, F.R.C.P. (Edin.), D.C.H. (Lond.), F.A.A.P. (Hon.) Professor and Head of the Department of Pediatrics, Patna University, and Kaleshwer Prasad, M.B.,B.S. (Patna) Post-graduate Student, Department of Pediatrics, Children’s Hospital, Patna Medical College Hospital, Patna, India.
MATERIAL AND METHODS
Seven cases of infective hepatitis and three cases of cirrhosis of the liver from the Hospital for Children, Patna Medical College Hospital, were included in his study. Thorough clinical examination was carried out before starting the trial of Liv.52, a product of The Himalaya Drug Co., containing Capparis spinosa (Kabra), Cichorium intybus (Kasni), Solanum nigrum (Makoi), Cassia occidentalis (Kasondi), Terminalia arjuna (Arjun), Achillea millefolium (Gandana), Tamarix gallica (Jhau).
Laboratory investigations were carried out in the Post-graduate Laboratory attached to the Department of Pediatrics, Patna University. The results of the trial are presented in the following tables.
Table 1: Showing Analysis of Cases of Infective Hepatitis and Cirrhosis |
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Type of case |
No. |
Age Range |
Sex |
Remarks |
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Male |
Female |
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Cirrhosis of Liver |
3 |
3-10 years |
2 |
1 |
Advanced type of Cirrhosis |
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Infective Hepatitis |
7 |
3-5 years |
7 |
Nil |
All with Jaundice and liver enlargement |
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|
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Table 2: Showing Presenting Features in Cases of Infective Hepatitis |
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Presenting Features |
No. of cases |
Percentage |
Pain abdomen |
4 |
57% |
Loss of appetite |
7 |
100% |
Jaundice |
7 |
100% |
Diarrhoea |
4 |
57% |
Low grade fever |
6 |
85% |
Liver enlargement |
7 |
100% |
Oedema of lower limbs |
4 |
57% |
Table 3: Showing Presenting Features in Cases of Cirrhosis |
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Presenting Features |
No. of cases |
Percentage |
Ascites |
3 |
100% |
Oedema of lower limbs |
2 |
66% |
Haematemesis and Melena |
2 |
66% |
Jaundice |
1 |
33% |
Epistaxis |
1 |
33% |
Table 4 : Showing SGPT Serum Bilirubin before and after Liv.52 Therapy in Infective Hepatitis |
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Case No. |
Type of Case |
Serum bilirubin before therapy |
SGPT Before therapy |
Serum bilirubin after therapy |
SGPT After therapy |
1. |
Infective hepatitis |
3 mgm/100cc |
45 Units/L |
1.5 mgm/100cc |
30 Units |
2. |
" " |
3.5 mgm/100cc |
42 Units/L |
1.2 mgm/100cc |
30 " |
3. |
" " |
2.8 mgm/100cc |
40 Units/L |
0.8 mgm/100cc |
40 " |
4. |
" " |
1.8 mgm/100cc |
30 Units/L |
0.6 mgm/100cc |
34 " |
5. |
" " |
6.3 mgm/100cc |
60 Units/L |
1.3 mgm/100cc |
30 " |
6. |
" " |
4.8 mgm/100cc |
68 Units/L |
1.0 mgm/100cc |
20 " |
7. |
" " |
1.3 mgm/100cc |
54 Units/L |
1.0 mgm/100cc |
48 " |
8. |
Cirrhosis of Liver |
3.5 mgm/100cc |
70 Units/L |
0.8 mgm/100cc |
30 " |
9. |
" " |
1.3 mgm/100cc |
80 Units/L |
1.4 mgm/100cc |
58 " |
10. |
" " |
1.4 mgm/100cc |
50 Units/L |
1.5 mgm/100cc |
30 " |
Table 5 : Showing Results of Therapy after Liv.52 in Infective Hepatitis |
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Group No. |
Dose of Liv.52 |
Duration of Treatment |
Cured |
Improved |
Poor |
Severe 4 |
½ T.S.F. t.d.s. |
3 weeks |
3 |
0 |
1 |
Moderate 2 |
½ T.S.F. t.d.s. |
2 weeks |
2 |
0 |
0 |
Mild 1 |
½ T.S.F. t.d.s. |
1 week |
1 |
0 |
0 |
The therapeutic results were assessed according to the following criteria : Cured — Symptom-free, normal serum bilirubin and SGPT normal. Improved — As above, but raised serum bilirubin and SGPT. Poor — Persistence of symptoms, jaundice and raised serum bilirubin and SGPT. |
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Table 6 : Showing the Result of Therapy in Cirrhosis of Liver |
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Type of case |
Good |
Fair |
Poor |
|
Cirrhosis of Liver |
3 |
1 |
1 |
1 |
SUMMARY
Seven patients suffering from infective hepatitis were treated with Liv.52 and they were divided into mild, moderate and severe groups according to the severity of clinical features and cases in each group were treated with half t.s.f. of Liv.52 thrice daily, with usual supportive medical treatment but none of them received corticosteroids.
Refference: http://www.himalayahealthcare.com/pdf_files/liv206.pdf