Liv.52 Studies in Acute Hepatitis
Vimala Ramalingam, Sundaravalli, N. and Balagopal Raju, V. Institute of Child Health and Hospital for Children, Egmore, Madras, India.
ABSTRACT
Of 250 cases of acute hepatitis studied and followed for 1 year, half were given Liv.52 and the other half either steroid therapy or placebo. The efficacy of the drug with regard to clinical, biochemical and pathological improvement is discussed. Liv.52 restored the liver functions earlier without any side effects.
INTRODUCTION
The incidence of acute hepatitis in the Institute of Child Health and Hospital for Children, Egmore, Madras-8 is nearly 250 cases per year. Some of them go into complications like acute liver cell failure and a few advance to cirrhosis liver. Drug trial with *Liv.52 was undertaken with a view to study the efficacy of the drug in acute hepatitis in comparison to steroid therapy and placebo.
* Liv.52 is a combination of indigenous drugs said to be widely used in cases of liver diseases. It contains:
Capparis spinosa 65 mg Cichorium intybus 65 mg Solanum nigrum 32 mg Cassia occidentalis 16 mg Terminalia arjuna 32 mg Achillea millefolium 16 mg Tamarix gannlliea 16 mg Mandur bhasma 33 mg per tablet.
It is available in the form of drops where 8 drops = 1 tablet.
MATERIAL AND METHODS
Two hundred and fifty cases of acute hepatitis between 1-12 years of age were studied between September 1969 and end of November 1970. Detailed history and physical examination was done in all and only those which satisfied all criteria of acute hepatitis were taken for study. About 125 cases were given Liv.52 (Group I) while another 125 cases served as control. Of the control group, 35 were treated with Prednisone and antibiotics (Group II), the other 90 were treated with vitamin C and B complex tablets (Group III).
All were followed every week for the first 3 months and then monthly for next 6 months and finally once in 3 months, those which could not be followed regularly were excluded. Liv.52 was given as drops or tablet depending upon the age; above 5 years - 2 tablets thrice daily for 3 months, 2 to 5 years - 1 tablet thrice daily for 3 months, below 2 years 15-20 drops thrice daily for 3 months. Vitamin C and B complex were given as 1 tablet thrice daily for 3 months, Prednisone as 1 mg/kg/day for 2 weeks and ½ mg/kg/day for next 2½ months.
Liver function tests were done at the first visit and then every week till they became normal.
Liver biopsies were also done at the time of acute hepatitis in 112. Repeat biopsies were done (once in 3 months) in 52.
Table I |
||||||
No. |
1 year 10 |
1-3 year 176 |
3-12 year 64 |
|||
|
M |
F |
M |
F |
M |
F |
250 |
6 |
4 |
102 |
74 |
40 |
24 |
| Table II | |||
Income in Rs. |
|||
No. |
100 |
100-200 |
300 |
250 |
206 82% |
39 16% |
5 2% |
Table III: Symptoms on Admission |
||||
|
Absent |
+ |
++ |
+++ |
Anorexia |
42 |
66 |
83 |
59 |
Fever |
67 |
105 |
49 |
20 |
Vomiting |
72 |
134 |
34 |
10 |
High coloured yellow urine |
— |
44 |
120 |
86 |
Pain Abdomen |
75 |
125 |
50 |
— |
Jaundice |
33 |
75 |
102 |
40 |
Liver |
— |
50 |
148 |
52 |
Spleen |
235 |
15 |
— |
— |
Oedema |
208 |
21 |
11 |
10 |
Refference: http://www.himalayahealthcare.com/pdf_files/liv205.pdf
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